Safety and activity of anti-mesothelin antibody-drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study.

In the first in human phase I study of anetumab ravtansine, a positive trend was observed between mesothelin expression and anti-tumor activity in the ovarian cancer cohort. 11 In this phase Ib study, in patients with high mesothelin expression and ≤3 prior lines of systemic therapies, anetumab ravtansine plus pegylated-liposomal doxorubicin showed an overall response rate of 42.1% with a median progression-free survival of 8.5 months, suggesting the significance of identifying a target patient population in platinum-resistant ovarian cancer.

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