To simplify the model, only the effects of weight on K rel and hepatic function on CL DXd were kept in the model: this was because weight was the most influential covariate on DXd‐conjugated antibody clearance, and hepatic function but not weight showed an apparent trend on the η –CL DXd versus covariate plots.
← all excerpts
Population Pharmacokinetics of Patritumab Deruxtecan in Patients With Solid Tumors.
1
—
—