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Population Pharmacokinetics of Patritumab Deruxtecan in Patients With Solid Tumors.

J Clin Pharmacol · 2023 · PMC10087001 · PMID 36053771

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an apparent trendno p-value reported
To simplify the model, only the effects of weight on K rel and hepatic function on CL DXd were kept in the model: this was because weight was the most influential covariate on DXd‐conjugated antibody clearance, and hepatic function but not weight showed an apparent trend on the η –CL DXd versus covariate plots.

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