Indeed, the acidic volume of the endolysosomal system, as measured with lysotracker Green DND‐26, revealed that CDC50A‐ and ATP8B1‐depleted cells displayed a highly significant increase in lysotracker intensity compared to control cells (Figure 3C ).
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The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages.
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