Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects.

In particular, the Aβ 42 -associated CpGs and pTau 181 -associated CpGs remained highly significant, with P- values ranging from 1.10 × 10 −10 to 1.81 × 10 −4 (Supplementary Table 15 ), and 1.39 × 10 −8 to 2.92 × 10 −3 (Supplementary Table 16 ), respectively, indicating our results are robust to different algorithms for estimating cell type proportions.

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