Variability of Primary Sjögren's Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.

A highly significant association between HLA class II gene polymorphisms and circulating IFNα protein concentrations was identified.

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Significant associations between IFNα concentrations and the B cell activation markers (B2M, BAFF), immunoglobulin free light chains, and CCL19 were observed; however, for IFNγ, associations with these markers were weaker and barely significant (Supplementary Figures 3A and 3B , available on the Arthritis & Rheumatology website at https://onlinelibrary.wiley.com/doi/10.1002/art.42265 ).

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