LPS Administration during Fertilization Affects Epigenetic Inheritance during Embryonic Development.

Animals (Basel) · 2023 · PMC10093599 · PMID 37048391

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an increasing trendp < 0.1so close (0.05 < p ≤ 0.1)

Compared with the control group, the expression of Tnf-α did not significantly change following LPS administration, whereas that of Il-1β and Il-6 demonstrated an increasing trend following the administration of 200 μg/kg LPS ( p < 0.1) and significantly increased with 1000 μg/kg LPS ( Figure 2 , p < 0.001). 3.2.

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a decreasing trendp < 0.1so close (0.05 < p ≤ 0.1)

However, the development rate of the 10 μg/mL LPS group displayed a decreasing trend in the 2-cell stage (95.0%, p < 0.1) compared with the control group (99.4%) and a significant decrease after the 4-cell stage (4-cell 83.0%, morula 71.0%, and blastocyst 62.0%, p < 0.05) compared with the control group (4-cell 93.6%, morula 84.9%, and blastocyst 82.0%). 3.3.

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