1,3,8-Triazaspiro[4.5]decane Derivatives Inhibit Permeability Transition Pores through a F_O-ATP Synthase c Subunit Glu¹¹⁹-Independent Mechanism That Prevents Oligomycin A-Related Side Effects.

Despite not being statistically significant, we found a decreasing trend in PTP activity after the use of PP11 in cells expressing ATP5G1 L117A , indicating that the inhibitory effect of this compound was not completely suppressed, and that this amino acid might be less important for Csub binding compared with Leu 123 ( Figure 3 A).

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