Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders.

These observations are highly significant as they highlight the need for assessments at the single subject level since underlying biological processes such as CSF-to-blood clearance capacity are highly individual 14 .

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For tau brain clearance, the extravascular clearance route via CSF and meningeal lymphatics to blood may be significant.

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