The organization and sequence variation of human rDNA units is likely to be highly significant, both because NORs are the locus of ribosome biogenesis and because they have also been implicated in processes as varied as cellular stress response, mitosis and cell proliferation, and specific age-related pathology (summarized in [ 5 ]).
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Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli.
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