Antibacterial activity and mechanism of sanguinarine against <i>Staphylococcus aureus</i> by interfering with the permeability of the cell wall and membrane and inducing bacterial ROS production.

At 6 h, as the AKP activity of each concentration increased, there was a significant rise at 8 × MIC ( P < 0.05 ); and at 12 and 24 h, there was even a highly significant rise at 8 × MIC ( P < 0.01 ), which figured that a high concentration of SGCH could effectively disrupt the cell wall of SA , causing leakage of intracellular AKP and thus increasing extracellular AKP activity. 3.6.

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