Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids.

Group differences in associations between emotion-induced brain activity and ISO/ALLO levels The association between task-related brain activity and ISO/ALLO serum levels was significantly different between subjects with PMDD and controls in the late-luteal phase in a cluster straddling the right parahippocampal gyrus (PHG) and right amygdala ( p FWE < 0.05, TFCE) and marginally significant in the right fusiform gyrus (FuG) ( p FWE < 0.10, TFCE) (Fig. 3 , Table S6 ).

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