Neonatal Tfh cells induced by HA/CAF01 showed lower levels of IL2Rα (CD25) but not of IL2Rβ when compared to the ones elicited by HA/GLASE, although only in the CAF01 group we observed a decreasing trend in IL2Rβ expression between effector T and Tfh cells ( Figure 6E ).
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C-type lectin receptor agonists elicit functional IL21-expressing Tfh cells and induce primary B cell responses in neonates.
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