highly significantP = 1.8 × 10 −20
Depression was a highly significant ( P = 1.8 × 10 −20 ) risk factor for AF recurrence after CA (RR: 2.3, 95% CI: 1.75–2.9), supported by suggestive evidence. 39 The mechanism of this association is unclear; however, it has been suggested that depression may be associated with chronic inflammation and can increase sympathetic activit