Amp(1q) and tetraploidy are commonly acquired chromosomal abnormalities in relapsed multiple myeloma.

2 Although only a small proportion of drivers are usually tested with FISH, some of the tested abnormalities are clinically highly significant, as also shown by the sequencing of a large data set from the Myeloma Genome Project. 13 Specifically, amp(1q) and del(17p) along with TP53 mutations are associated with an adverse outcome in this study.

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