The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system.

Importantly, we further show that co-treatment of primary neurons with 4 μM YM201636 and 50 μM ML-SA1 led to both a significant reduction in the intensity of Rab7 immunopositive vesicles in the perinuclear region and a highly significant reduction in the number of vacuoles that were immunolabelled with Rab7 at 24 h, both of which were restored to control levels ( Fig. 6 B).

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