borderline significantp = 0.05
rvention with vorapaxar as compared with placebo. PAI-2 decreased significantly in favor of vorapaxar as compared with placebo in the total study population ( p = 0.025) at late FU, essentially driven by changes in the post-MI (chronic CHD) patients ( p = 0.054), whereas vorapaxar induced a borderline significant increase ( p = 0.05) in NSTEMI (TRACER) patients during short-term therapy ( Table 6 ).