Abrupt termination of vitamin C from ICU patients may increase mortality: secondary analysis of the LOVIT trial.

However, the highly significant 2.28-fold increase in mortality during the 3 days immediately after the termination of vitamin C, with no significant evidence of harm thereafter, is consistent with the notion that it was the abrupt termination of vitamin C which caused the harm in the participants randomized to the 4-day vitamin C administration.

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