Human milk oligosaccharides induce acute yet reversible compositional changes in the gut microbiota of conventional mice linked to a reduction of butyrate levels.

HMO-induced expansion of Phocaeicola and reductions in Lacrimispora is associated with reduced faecal acetate and butyrate levels A highly significant negative correlation was found between the relative abundance of Phocaeicola and Lacrimispora (Fig. 7A , Rho = −0.614 , P < .001, Spearman's rank correlation).

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