A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases.

Although disease genes show a marginally significant ( p < 0.031) difference in their expression levels compared with non-disease associated genes ( panel A of Fig K in S1 Text ), disease genes have a significantly higher percentage of differentially stable genes, particularly for substance abuse, (mean DS = 0.702, p < 4.7 × 10 − 21 ), psychiatric (DS = 0.675, p < 3.17 × 10 − 17 ), and movement disorders (DS = 0.635, p < 1.21 × 10 − 17 ) ( panel B of Fig K in S1 Text ).

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Brain disease genes do not have significant expression differences from non-brain related genes, but both are different from non-disease associated genes with marginal significance.

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