Prescribing Trends for the Same Patients with Schizophrenia Over 20 Years.

The complete monotherapy rates for SGAs without other psychotropic medications in 2001, 2006, 2011, 2016 and 2021 were only 0.7%, 2.7%, 3.5%, 5.0% and 6.3%, respectively ( Table 1 ), with an increasing trend (χ2 = 37.6, df = 1, p = 9.0×10 −10 ). The rates of FGA use in 2001, 2006, 2011, 2016 and 2021 were 85.6%, 77.5%, 70.7%, 65.1% and 54.7%, respectively ( Table 1 and Figure 1A ), with a decreasing trend (χ2 = 190.2, df = 1, p < 2.2×10 −16 ).

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Trends of Antipsychotic Prescriptions The rates of antipsychotic monotherapy in 2001, 2006, 2011, 2016 and 2021 were 32.0%, 33.7%, 32.8%, 37.6% and 41.5%, respectively, with an increasing trend (χ2 = 16.3, df = 1, p = 5.4×10 −5 ) ( Table 1 ).

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