The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome?

Hum Genomics · 2023 · PMC10122315 · PMID 37085889

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The association with UBE2DNL in our data also appears to be credible for three reasons: 1) the CpGs remained significant even after adjusting for covariates (see Additional file 2 ), 2) there is a highly significant DMR in this region, and 3) the data from the independent CHART cohort showed a DMR in this pseudogene (data not shown) and differential DNAm at these two CpGs in ART vs. non-ART boys (Additional file 1 : Figure S8).

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