highly significantp < 1 × 10 –11
8 b) and had highly significant enrichment of interactions between them (STRING: expected number of edges: 5; number of edges: 28; PPI enrichment p-value: ****p < 1 × 10 –11 ) , while random samples of 43 peaks from either all GWAS ALS genes or from all epiChromALS peaks showed no functional enrichment, suggesting a mechanistic link between these genes, neuronal development/function, and epigenetic mechanisms.