Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways.

Sci Rep · 2023 · PMC10126102 · PMID 37095160

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highly significantno p-value reported

Other highly significant adaptive pathways relate to T-cell receptor-induced activation of cytotoxic T-cells and have not been described in cholangiocarcinoma including cluster of differentiation 3 (CD3) phosphorylation (FDR 0.009), translocation of zeta-chain associated protein kinase 70 (ZAP70) to the immunological synapse (FDR 0.039) and the TH1TH2 pathway (FDR 0.02).

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