oHSV-P10 reduces glioma stem cell enrichment after oncolytic HSV therapy.

These results are highly significant; the residual tumor cells that escape oncolytic onslaught (hereby referred to as escapers) are responsible for disease recurrence. oHSV-P10 decreases GSC enrichment in residual tumor escapers Tumor suppressor PTEN is a phosphatase known to function primarily as a lipid phosphatase that can reverse the pro-mitogenic signaling promoted by a PI3K/AKT signaling cascade. 13 , 14 , 15 This implies that PTEN expression might overcome virotherapy-induced GSC enrichment in brain tumors.

also in 132,142 other papers