Exaptation of Inactivated Host Enzymes for Structural Roles in Orthopoxviruses and Novel Folds of Virus Proteins Revealed by Protein Structure Modeling.

mBio · 2023 · PMC10128050 · PMID 37017580

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highly significantno p-value reported

Especially notable is the case of OPG148 (A20R), which showed highly significant structural similarity to DNA ligases, particularly bacterial NAD-dependent ones ( Fig. 2C ).

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