Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infection Model.

mBio · 2023 · PMC10128057 · PMID 36809085

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highly significantno p-value reported

To evaluate whether we can reproduce the human HEV-3 p6 results utilizing the rabbit HEV-3ra LR model system, especially given our observation of the highly significant enhancement of Y1320H on HEV-3ra LR replication ability, we further generated the LRG_Y1320H/K1383N double mutant and compared its replication efficiency with LRG_WT and LRG single mutants.

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