Nrf2^-/- regulated lung DNA demethylation and <i>CYP2E1</i> DNA methylation under PM_2.5 exposure.

We found that CpG4 showed an increasing trend after PM 2.5 exposure in WT and Nrf2 knockout mice, and the rest had no significant changes ( Figure 4B ), nevertheless, LINE1 mean methylation levels did not change significantly ( Supplementary Figure S4 ).

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