Natural aging and Alzheimer's disease pathology increase susceptibility to focused ultrasound-induced blood-brain barrier opening.

Sci Rep · 2023 · PMC10130033 · PMID 37185578

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may not be significantno p-value reported

While the mechanisms of BBB reinstatement are still under active investigation, the data presented herein suggests that the mechanism of BBBC following FUS-BBBO may not be significantly compromised by age or AD pathology, but rather that BBBO volume may be a better predictor of BBBC timelines.

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