Time Trends in Prognosis Within 1 Year After Incident AF Diagnosis Except for the cumulative incidence of gastrointestinal bleeding, which remined generally consistent ( Table 3 ), the 1-year cumulative incidences of the investigated clinical events all showed a decreasing trend from 2014 to 2018, including ischemic stroke (from 1.63% [95% CI, 1.52%-1.73%] to 1.39% [95% CI, 1.30%-1.48%]), major bleeding (from 2.50% [95% CI, 2.37%-2.63%] to 2.07% [95% CI, 1.96%-2.19%]), ICH (from 0.60% [95% CI, 0.54%-0.67%] to 0.40% [95% CI, 0.36%-0.46%]), and all-cause mortality (from 19.13% [95% CI, 18.80%-19.45%] to 17.67% [95% CI, 17.37%-17.97%]) ( Table 3 ).
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Time Trends in Patient Characteristics, Anticoagulation Treatment, and Prognosis of Incident Nonvalvular Atrial Fibrillation in the Netherlands.
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