a slight trendp = 0.07
Comorbidities Interplay and Adverse Event Rate Overall, patients with headaches did not differ from NONH in terms of comorbidities: neurological ( p = 0.67), gastrointestinal ( p = 0.54), psychiatric ( p = 0.20), ophthalmologic ( p = 0.95), and metabolic ( p = 0.31) fields were not significantly different among the two groups, while only a slight trend was found for cardiovascular comorbidity ( p = 0.07), which was more represented in patients with headaches.