highly significantp < 0.0002
The Ctn reference ranges determined in this way for patients with nodular thyroid findings (90% confidence intervals) were <3.0 to 9.1 pg/mL for women and <3.0 to 14.1 pg/mL for men, i.e., very similar to the reference ranges specified by the manufacturer and with a highly significant sex difference ( p < 0.0002).