Prolonged Primary Rhinovirus Infection of Human Nasal Epithelial Cells Diminishes the Viral Load of Secondary Influenza H3N2 Infection via the Antiviral State Mediated by RIG-I and Interferon-Stimulated Genes.

With a longer duration of Rupintrivir treatment, there was no significant alteration in RIG-I mRNA expression but there was a decreasing trend in RIG-I protein level during secondary H3N2 infection of hNECs as compared to that without treatment ( Supplementary Figure S6C,D ).

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