TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome.

Front Immunol · 2023 · PMC10140348 · PMID 37122710

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an increasing trendno p-value reported

As shown in Figures 3B–D , compared with the control group (normal, 5.5mM), the expression of NLRP3, ASC, GSDMD, Caspase-1, IL-1β, IL-18 and IL-6 were upregulated after ATP treatment, and the majority of these proteins showed an increasing trend after TIGAR knockdown when cultured in high glucose medium, while the diversity was slight under normal glucose(5.5mM) treatment.

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