20 reported a decreasing trend in IL-10, but the decline was observed later (D7 and D14) than the decline of pro-inflammatory cytokines in the control group (D4 and D7).
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Systematic review and meta-analysis of mesenchymal stromal/stem cells as strategical means for the treatment of COVID-19.
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24 On the other hand, an increasing trend was observed for anti-inflammatory cytokine, IL-10 in the MSC-treated group. 21 , 22 In the study by Dilogo et al. , 22 the increasing trend of IL-10 was observed for up to 7 days following MSC infusion.