Increased Clinical Signs and Mortality in IFNAR^(-/-) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype.

These may be significant after vaccination campaigns using monovalent, serotype-specific vaccines (particularly if they are based primarily on VP2 and VP5 subunits) with potential to enhance the persistence of attenuated BTV vaccine strains that have previously been used in the field [ 31 , 53 , 54 ].

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