APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility.

21 Our results align with previous studies on the effect of cholesterol loading on the mobility of membrane proteins in living cells, substantially different from the results obtained in liposomes, showing similar effects on the diffusion of some raft and non-raft proteins, 24 and more or less significant effects on mobility, sometimes with opposite results. 46 As the plasma membrane is the most raft-enriched membrane compartment in the cell, in which proteins with high raft affinity tend to localize, 47 it seems unlikely that a different dynamic behavior would occur on the endosome membrane.

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