highly significantp = 0.0003
1 A,) resulting in a highly significant reduction in the cumulative EAE score (control 35.69 ± 2.45; H398, 16.96 ± 2.52, p = 0.0003; EHD-sc-mTNF R2, 27 ± 3.55; H398 + EHD-sc-mTNF R2, 18.67 ± 2.97, p = 0.0009; Fig. 1 B).
1 A,) resulting in a highly significant reduction in the cumulative EAE score (control 35.69 ± 2.45; H398, 16.96 ± 2.52, p = 0.0003; EHD-sc-mTNF R2, 27 ± 3.55; H398 + EHD-sc-mTNF R2, 18.67 ± 2.97, p = 0.0009; Fig. 1 B).
However, the increase in the ratio of pNF-κB/ NF-κB in the combination treatment group did not quite reach significance (control 0.59 ± 0.12; H398, 0.69 ± 0.13; EHD-sc-mTNF R2 1.00 ± 0.03, p = 0.0245; H398 + EHD-sc-mTNF R2, 0.94 ± 0.057) (Fig. 4 J–L).