Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition.

Previously, we demonstrated that Palbociclib treatment results in a highly significant survival advantage to mice bearing Med-1712FH (SHH) patient-derived orthotopic xenograft (PDOX) MB [ 16 ], although 80% of the tumours relapse upon the cessation of treatment.

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