High-Contrast PET Imaging with [¹⁸F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.

Overall, this improvement is highly significant since it cut the amount of nonradioactive mass dose of the NT160 by >50% thus enabling performing blocking (target engagement) studies in vivo and will likely enable clinical translation of [ 18 F]NT160 by starting with larger amounts of radioactivity (i.e., >3.0 Ci).

also in 132,142 other papers