Association analysis between the TLR9 gene polymorphism rs352140 and type 1 diabetes.

Front Endocrinol (Lausanne) · 2023 · PMC10150994 · PMID 37139337

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a decreasing trendno p-value reported

In NOD mice with TLR9 knockout, the frequencies of plasmacytoid dendritic cells and diabetogenic CD8+ T cells show a decreasing trend accompanied by lower levels of IFN-α in pancreatic lymph nodes, which may inhibit the development of T1D ( 17 ).

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