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Klotho's impact on diabetic nephropathy and its emerging connection to diabetic retinopathy.

Front Endocrinol (Lausanne) · 2023 · PMC10151763 · PMID 37143722

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a decreasing trendno p-value reported
Klotho levels show a decreasing trend in both type 1 diabetes mellitus (T1DM) ( 26 – 28 ) and T2DM ( 29 – 31 ), and it is even depleted in the pancreas of diabetic patients ( 32 ).

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