an increasing trendP < .001
Among patients without calcification at baseline, by the end of 4-year follow-up, 42.7% had CAC progression, 57.5% had AAC progression, 33.5% had CVC progression, and 68.5% had total VC progression, which represented an increasing trend over the study period ( P < .001 for trend for all comparisons) (eTable 2 in Supplement 1 ).