In the multivariate Cox regression model investigating TTT in PMF patients, association of higher ePVS with increased thrombotic risk (adjusted HR 4.79, 95% CI (1.43-16.01), P = 0.011) was present independently of JAK2 mutational status (adjusted HR = 3.75, 95% CI (1.0-14.09), P = 0.049), WBC (adjusted HR 1.02, 95% CI (1.01-1.04), P = 0.002) and chronic kidney disease (adjusted HR = 3.56, 95% CI (1.29-9.8), P = 0.013), whereas cardiovascular risk-factors (adjusted HR = 6.37, 95% CI (0.76-53.22), P = 0.086) retained marginal significance adjusted additionally for age, sex, history of thrombosis and haematocrit.
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Higher estimated plasma volume status is associated with increased thrombotic risk and impaired survival in patients with primary myelofibrosis.
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