CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease.

Nat Aging · 2023 · PMC10154225 · PMID 37117788

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CSF pT217/T217 had the highest correlation with amyloid PET Centiloid of all the measures (Spearman’s ρ = 0.76 (95% CI 0.73–0.79), which was almost significantly higher than Lumipulse Aβ42/Aβ40 ( ρ = −0.74 (−0.77 to −0.71), P = 0.08) and was significantly higher than p-tau217 concentration (ρ = 0.71 (0.67–0.74), P < 0.0001) (Supplementary Tables 4 and 5 ).

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