Quantification of the 6E10-positive deposits showed a slight increase in AM; Serf2 br −/− compared with AM, but this just failed to reach statistical significance in the Bonferroni corrected post-hoc comparison (two-way ANOVA: all 3m non-AM versus AM groups p bon < 0.0001; AM versus AM; Serf2 br −/− p bon = 0.063) ( Fig 5F , left panel).
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Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
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