Novel tumor necrosis factor-related long non-coding RNAs signature for risk stratification and prognosis in glioblastoma.

We consistently observed a highly significant enrichment of tumorigenesis-related pathways and markers in the C2 molecular subtype with high TNF scores, such as the ECM receptor interaction, JAK Stat signaling pathway, VEGF signaling pathway, and focal adhesion pathways, which were significantly enriched, while immune-related T cell receptor signaling pathway, natural killer cell mediated cytotoxicity, and toll-like receptor signaling pathway were similarly significantly enriched, and these results tentatively revealed the mechanism for poor prognosis in the high-risk group.

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