The mechanism of liver X receptor regulates the balance of glycoFAsynthesis and cholesterol synthesis in clear cell renal cell carcinoma.

Dear Editor, Renal cell carcinoma (RCC) is a prevalent cancer, ranking among the top ten worldwide cancers and accounting for 2% of all cancers globally, with an increasing trend annually. 1 Clear cell renal cell carcinoma (ccRCC), arising from proximal renal tubular cells, is highly malignant, accounting for all genitourinary tumours. 2 Approximately 30% of ccRCC cases tend to metastasize, with poor prognosis. 3 Early diagnosis of ccRCC is challenging as clinical manifestations are often elusive, and it lacks effective tumour markers while being insensitive to radiotherapy and chemotherapy.

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