Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase.

Proc Natl Acad Sci U S A · 2023 · PMC10160976 · PMID 37094117

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highly significantno p-value reported

APOC2 binding to the lid at 5 to 25 s was unequivocal and highly significant, but it was also highly dynamic; deuterium uptake was nearly maximal after 100 s ( Fig. 3 B and C ).

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