Evaluation of serum levels of Irisin as a marker of endothelial dysfunction in patients with type 2 diabetes mellitus.

A p ‐value was used to evaluate the significance of the results, which can be classified as non‐significant when the p ‐value is >.05, significant when the p ‐value is ≤.05, and highly significant when the p ‐value is ≤.001. 3.

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In a study of 117 healthy middle‐aged women with BMI ranging from 20.0 to 47.7 kg/m 2 , circulating irisin had positive associations with fat‐free mass and a positive trend with BMI. 32 Obese patients have higher circulating irisin levels compared with normal‐weight controls and anorexic patients, and irisin has a positive correlation with body weight and BMI.

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