Terminal bridging of siRNA duplex at the ribose 2' position controls strand bias and target sequence preference.

Mol Ther Nucleic Acids · 2023 · PMC10165404 · PMID 37168798

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a slight trendno p-value reported

A significant silencing activity of the passenger strand was observed only when the ESB RNA was 22 bp, with a slight trend toward dose-dependent passenger strand activity at 21 bp.

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